To shed light on the bone metastatic process, B2B aims to develop a breakthrough technology that for the first time dissects the steps of spontaneous breast cancer metastasis to the bone and captures the 3D complexity of the process. he B2B device includes macro-size organoids from breast tumor and bone, assembled together with a macro-to-micro vascular network. This level of physiological complexity is required to capture the key elements of the metastatic process.
Partners: CNR, UNIVERSITEIT MAASTRICHT, CICT Ltd, R4L, IN SRL, ERASMUS MC, BIOEMTECH
IEIIT is the Coordinator of the all project and responsible of all the activities related to the design and the realization of the multi-chamber perfusing tissue culture system to be used as 3D tool for in vitro modeling of breast cancer metastasis to bone. CNR leads also the fluid dynamic simulation of the circulating fluid flow that connects the primary breast tumor tissue with the metastatic target tissue (i.e. bone ossicle).
European Project FET OPEN-1-2016 2017 Pillar Excellence Science
Total Funding: 3.799.371,25 euro
Timeline: July 2018 - July 2022