Breakthrough model of breast cancer metastasis to the bone

The B2B H2020 Pathfinder project is just ended


The main objective of the EU-funded B2B project was to develop an in vitro model of breast cancer metastasis to bone, one of the most common sites of breast cancer cell colonisation. In vitro models typically rely on monolayer cell cultures or tumour spheroids and lack the 3D dynamic complexity of native organs and the in vivo environment. Animal models, on the other hand, do not recapitulate human physiology and are not clinically relevant for predicting drug response in humans. “B2B has developed a one-of-a-kind device that uses patient derived macroscale tumour tissue of clinically relevant dimensions, cultured within a self-assembled microvascular capillary network,” explains project coordinator Silvia Scaglione.

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